Disrupted structure and aberrant function of CHIP mediates the loss of motor and cognitive function in preclinical models of SCAR16
Immuno-stained sagittal sections of either a wild-type mouse cerebellum (left) or a cerebellum isolated from a mouse engineered with the T246M mutation in CHIP (right). The T246M mutation results in a robust decrease in CHIP expression (white) in the Purkinje cells, ultimately leading to the degeneration of Purkinje cells and a loss in motor function, mimicking the human disease known as SCAR16. In red is a false coloring of the methyl blue counterstain, indicating the molecular layer of the cerebellum.
Way to go team! Our recent paper in JPM is now the featured item on the cover. This was a big effort by all, including Kaitlin Lenhart…great job!