Excited to showcase our latest manuscript that inspired our design of the journal cover. Read the article, co-authored by several undergraduates in our lab!
On The Cover: Functional CHIP is necessary for proper function of the cerebellum. Disease-causing mutations, represented by the space-filled side chains were found in the three functional domains of CHIP: the TPR domain (orange) that binds substrates, the coiled-coil domain (purple and magenta) that mediate the CHIP dimer interaction, and the Ubox (green) that interacts with E2-conjugating enzymes (cyan) through a protein-protein interaction (blue/yellow).