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Schisler Lab Welcomes BBSP Rotation Student, Owen Canterbury!

2022-11-07
Owen Canterbury

 

Owen is a first-year BBSP student currently rotating in the Schisler Lab. His research interests focus on mechanisms of proteolysis, their role in the development of disease states spanning cancer to cardiovascular conditions, and how cells use protein degradation as a means of cellular signaling. When he is not working in the lab, Owen can be found out running, hiking, or doing yard work

EXCITING NEWS!!! We have been selected for funding for our collaborative project: Machine Learning-enabled personalized medicine to improve severe COVID-19 outcomes

2022-10-14

Our project,Ā Machine Learning-enabled personalized medicine to improve severe COVID-19 outcomes was selected for funding of $1M by the NC Collaboratory. This is a partnership with SAS (Cary, NC) and at UNC-CH, an MPI effort with our lab, Matt Wolfgang (micro), and Rob Hagan (DoM). Individuals hospitalized with infection-related respiratory symptoms are beyond the protection of vaccines and anti-viral drugs, and there is a dire need for personalized therapies. A personalized approach or precision medicine contrasts with current clinical practice, which relies on standardized therapies that show heterogeneous benefits across large populations. One major roadblock to precision medicine related to lung infections and COVID-19, is the lack of analytical tools that can predict in real-time which therapies will be most beneficial on an individual basis. The goal of our project is to leverage our new understanding of varied host responses to guide personalized treatments using machine learning. We will merge organ-specific molecular phenotyping of diseased patients with electronic health records (EHR) using machine learning-powered data modeling and apply the resulting predictive models to improve clinical care and disease outcomes in the general population.

Hot off the press! Schisler Lab Paper news!

2022-06-20

Co-authors Selin Altinok and Jonathan Schisler participated in the formal analysis and investigation on:

The molecular basis of spinocerebellar ataxia type 48 caused by aĀ de novoĀ mutation in the ubiquitin ligase CHIP

 

Co-authors Rebekah Sanchez-Hodge, Selin Altinok, Leah Oswalt, and Dr. Jonathan Schisler worked with collaborators in the Netherlands on this Nature Communications cancer piece:

Ubiquitin ligase STUB1 destabilizes IFNĪ³-receptor complex to suppress tumor IFNĪ³ signaling

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2022 Human Research Program Investigatorsā€™ Workshop

2022-01-19

Are you interested in learning more about the Schisler Lab and operations in space? Register for the 2022 Human Research Program Investigatorsā€™ Workshop on 2/07-2/10. This workshop aims to provide an informal, collegial atmosphere for cross-disciplinary interaction. Click on the graphic below to sign up; we hope to see you there!