Skip to main content

The Schisler Lab welcomes new rotation student, Jacob Pantazis


The Brown and Schisler lab put out a call for rotation students who want a unique co-mentoring opportunity, and Jacob was the first to answer. I had the chance to interview Jacob for his interview into our BBSP program, and it is great to see him in our lab now as a rotation student! He will be working with Selin and the Brown lab on purification and analyses of mutant forms of the enzyme CHIP.

Womp rats beware

Opening the door for CHIP pharmacology


A new study published from a great collaboration with David Kass, Mark Ranek, and the Hopkins crew is now out at Nature Communications; read and share! Strong work by Becky Sanchez, Cornelia Virus, and Team CHIP.

CHIP phospho-memetic (SE) protects the heart from damage caused by heart attacks


New grant! Big news from the Schisler Lab


We are thrilled to announce a new five year grant to study and develop treatments for diseases that involve proteins important to a process known as protein quality control. Click and read more on Vital Signs!

File this under ‘Grants’, please and thank you!

The Head and the Heart


Great article featuring our ongoing collaboration with the Cohen lab! We are combining forces to biochemically modify the Tau protein, allowing us to understand how Tau functions, both in health and disease, so we can find better ways to treat Alzheimer’s.

Schisler and Cohen

Schisler Lab on the cover of JBC


Excited to showcase our latest manuscript that inspired our design of the journal cover. Read the article, co-authored by several undergraduates in our lab!

On The Cover: Functional CHIP is necessary for proper function of the cerebellum. Disease-causing mutations, represented by the space-filled side chains were found in the three functional domains of CHIP: the TPR domain (orange) that binds substrates, the coiled-coil domain (purple and magenta) that mediate the CHIP dimer interaction, and the Ubox (green) that interacts with E2-conjugating enzymes (cyan) through a protein-protein interaction (blue/yellow).