The Brown and Schisler lab put out a call for rotation students who want a unique co-mentoring opportunity, and Jacob was the first to answer. I had the chance to interview Jacob for his interview into our BBSP program, and it is great to see him in our lab now as a rotation student! He will be working with Selin and the Brown lab on purification and analyses of mutant forms of the enzyme CHIP.
A new study published from a great collaboration with David Kass, Mark Ranek, and the Hopkins crew is now out at Nature Communications; read and share! Strong work by Becky Sanchez, Cornelia Virus, and Team CHIP.
Great Department and research family here in PHCO. Thanks for your insight, Kaitlan!
A story in The Daily Tar Heel featuring lots of MHI faculty and our own Arjun Putcha! We are lucky to have great undergraduate researchers that make up a big part of our success. We may be limited in our time in lab, but we are still working hard remotely too. Be safe and wear a mask!
https://www.dailytarheel.com/article/2020/06/research-operations-opening
Read more about COV-IRT, some of our work on COVID-19, and join us in helping the world understand and develop treatments for COVID-19. A great write-up by Alyssa LaFaro. Check it out!!
We are thrilled to announce a new five year grant to study and develop treatments for diseases that involve proteins important to a process known as protein quality control. Click and read more on Vital Signs!
Great article featuring our ongoing collaboration with the Cohen lab! We are combining forces to biochemically modify the Tau protein, allowing us to understand how Tau functions, both in health and disease, so we can find better ways to treat Alzheimer’s.
Excited to showcase our latest manuscript that inspired our design of the journal cover. Read the article, co-authored by several undergraduates in our lab!
On The Cover: Functional CHIP is necessary for proper function of the cerebellum. Disease-causing mutations, represented by the space-filled side chains were found in the three functional domains of CHIP: the TPR domain (orange) that binds substrates, the coiled-coil domain (purple and magenta) that mediate the CHIP dimer interaction, and the Ubox (green) that interacts with E2-conjugating enzymes (cyan) through a protein-protein interaction (blue/yellow).
Todd Cohen, PhD, and Jonathan Schisler, PhD, will investigate the new ideas related to the regulation of the Tau protein, which plays a role in Alzheimer’s disease.
Could this protein protect people against coronary artery disease?
https://reliawire.com/cxcl5-coronary-artery-disease/