More here👉https://tinyurl.com/MHIsummer

Owen is a first-year BBSP student currently rotating in the Schisler Lab. His research interests focus on mechanisms of proteolysis, their role in the development of disease states spanning cancer to cardiovascular conditions, and how cells use protein degradation as a means of cellular signaling. When he is not working in the lab, Owen can be found out running, hiking, or doing yard work

Our project, Machine Learning-enabled personalized medicine to improve severe COVID-19 outcomes was selected for funding of $1M by the NC Collaboratory. This is a partnership with SAS (Cary, NC) and at UNC-CH, an MPI effort with our lab, Matt Wolfgang (micro), and Rob Hagan (DoM). Individuals hospitalized with infection-related respiratory symptoms are beyond the protection of vaccines and anti-viral drugs, and there is a dire need for personalized therapies. A personalized approach or precision medicine contrasts with current clinical practice, which relies on standardized therapies that show heterogeneous benefits across large populations. One major roadblock to precision medicine related to lung infections and COVID-19, is the lack of analytical tools that can predict in real-time which therapies will be most beneficial on an individual basis. The goal of our project is to leverage our new understanding of varied host responses to guide personalized treatments using machine learning. We will merge organ-specific molecular phenotyping of diseased patients with electronic health records (EHR) using machine learning-powered data modeling and apply the resulting predictive models to improve clinical care and disease outcomes in the general population.

Sarah is an Exercise Science/Pre-Med undergraduate student here at UNC

Mara is a Biology Major and Health and Society Minor

Joe Danica is a Neuroscience major

The Schisler lab is very excited to have this talented young lady join our crew!

Her focus will be on CHIP and Alzheimer’s disease pathology.

Co-authors Selin Altinok and Jonathan Schisler participated in the formal analysis and investigation on:

The molecular basis of spinocerebellar ataxia type 48 caused by a de novo mutation in the ubiquitin ligase CHIP

Co-authors Rebekah Sanchez-Hodge, Selin Altinok, Leah Oswalt, and Dr. Jonathan Schisler worked with collaborators in the Netherlands on this Nature Communications cancer piece:

Ubiquitin ligase STUB1 destabilizes IFNγ-receptor complex to suppress tumor IFNγ signaling

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