#teamscience #spacebiology

We were happy to contribute to a genetics study to improve rigor and reproducibility in mouse research. Even in our preclinical models of SCAR16/SCA48, we see clear impacts on the severity of phenotypes based on mouse strain.

https://www.genetics.org/content/early/2020/10/16/genetics.120.303596

Disrupted structure and aberrant function of CHIP mediates the loss of motor and cognitive function in preclinical models of SCAR16

Immuno-stained sagittal sections of either a wild-type mouse cerebellum (left) or a cerebellum isolated from a mouse engineered with the T246M mutation in CHIP (right). The T246M mutation results in a robust decrease in CHIP expression (white) in the Purkinje cells, ultimately leading to the degeneration of Purkinje cells and a loss in motor function, mimicking the human disease known as SCAR16. In red is a false coloring of the methyl blue counterstain, indicating the molecular layer of the cerebellum.

Read about the adverse effects of the most commonly prescribed fibrate in our CHIP knockout mice.

↓↓↓ CLICK HERE ↓↓↓

Way to go team! Our recent paper in JPM is now the featured item on the cover. This was a big effort by all, including Kaitlin Lenhart…great job!

Click and read about how your DNA affects your ability to perceive the taste of green vegetables and how that may affect a healthy heart!

Our latest prerprint is online! Huge team effort & remarkable project we participated in out in Lenoir County. Click and read!

Read about a great collaborative project we are involved in with the Fenton lab. Our first paper was published in JASN, click below and read all about it!