Todd Cohen, PhD, and Jonathan Schisler, PhD, will investigate the new ideas related to the regulation of the Tau protein, which plays a role in Alzheimer’s disease.
We are now located on the third floor of MBRB, Room 3336. Jonathan’s office is next-door in room 3340C. Come visit the new digs!
We have new undergraduate interns for 2019! So welcome to the team!
Disrupted structure and aberrant function of CHIP mediates the loss of motor and cognitive function in preclinical models of SCAR16
Immuno-stained sagittal sections of either a wild-type mouse cerebellum (left) or a cerebellum isolated from a mouse engineered with the T246M mutation in CHIP (right). The T246M mutation results in a robust decrease in CHIP expression (white) in the Purkinje cells, ultimately leading to the degeneration of Purkinje cells and a loss in motor function, mimicking the human disease known as SCAR16. In red is a false coloring of the methyl blue counterstain, indicating the molecular layer of the cerebellum.
Read about the adverse effects of the most commonly prescribed fibrate in our CHIP knockout mice.
↓↓↓ CLICK HERE ↓↓↓
Way to go team! Our recent paper in JPM is now the featured item on the cover. This was a big effort by all, including Kaitlin Lenhart…great job!
Click and read about how your DNA affects your ability to perceive the taste of green vegetables and how that may affect a healthy heart!
Collectively, this study identifies a novel means of preventing necroptosis in two in vitro models of cerebral ischemia injury through activating the expression of CHIP, and it may provide a potential target for the further study of the disease.