Disrupted structure and aberrant function of CHIP mediates the loss of motor and cognitive function in preclinical models of SCAR16
Immuno-stained sagittal sections of either a wild-type mouse cerebellum (left) or a cerebellum isolated from a mouse engineered with the T246M mutation in CHIP (right). The T246M mutation results in a robust decrease in CHIP expression (white) in the Purkinje cells, ultimately leading to the degeneration of Purkinje cells and a loss in motor function, mimicking the human disease known as SCAR16. In red is a false coloring of the methyl blue counterstain, indicating the molecular layer of the cerebellum.
Read about the adverse effects of the most commonly prescribed fibrate in our CHIP knockout mice.
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Way to go team! Our recent paper in JPM is now the featured item on the cover. This was a big effort by all, including Kaitlin Lenhart…great job!
Click and read about how your DNA affects your ability to perceive the taste of green vegetables and how that may affect a healthy heart!
Our latest prerprint is online! Huge team effort & remarkable project we participated in out in Lenoir County. Click and read!
Read about a great collaborative project we are involved in with the Fenton lab. Our first paper was published in JASN, click below and read all about it!
Featured on the cover, click and read about a new and exciting research focus of The Schisler Lab!