Featured on the covers of Cell and Cell Reports- more news press on recent publications on Space Biology
Both papers featuring the Schisler Lab landed on the cover with pictures from the ISS taken by Scott Kelly (one of the twins from the twin study, whose data we used in these papers)!
They got some nice press too:
https://www.nasa.gov/feature/ames/mitochondria-cell-science
https://www.cnn.com/2020/11/25/health/biology-of-spaceflight-studies-wellness-scn-trnd/index.html
https://www.popsci.com/story/science/spaceflight-human-body-effects/
da Silveira WA, Fazelinia H, Rosenthal SB, Laiakis EC, Kim MS, Meydan C, Kidane Y, Rathi KS, Smith SM, Stear B, Ying Y, Zhang Y, Foox J, Zanello S, Crucian B, Wang D, Nugent A, Costa HA, Zwart SR, Schrepfer S, Elworth RAL, Sapoval N, Treangen T, MacKay M, Gokhale NS, Horner SM, Singh LN, Wallace DC, Willey JS, †Schisler JC, Meller R, McDonald JT, Fisch KM, Hardiman G, Taylor D, Mason CE, Costes SV, Beheshti A. Cell. 2020 Nov 25;183(5):1185-1201.e20. doi: 10.1016/j.cell.2020.11.002. PMID: 33242417
Circulating miRNA Spaceflight Signature Reveals Targets for Countermeasure Development.
Malkani S, Chin CR, Cekanaviciute E, Mortreux M, Okinula H, Tarbier M, Schreurs AS, Shirazi-Fard Y, Tahimic CGT, Rodriguez DN, Sexton BS, Butler D, Verma A, Bezdan D, Durmaz C, MacKay M, Melnick A, Meydan C, Li S, Garrett-Bakelman F, Fromm B, Afshinnekoo E, Langhorst BW, Dimalanta ET, Cheng-Campbell M, Blaber E, Schisler JC, Vanderburg C, Friedländer MR, McDonald JT, Costes SV, Rutkove S, Grabham P, Mason CE, Beheshti A. Cell Rep. 2020 Nov 21:108448. doi: 10.1016/j.celrep.2020.108448. Online ahead of print. PMID: 33242410
The Schisler Lab welcomes new rotation student, Jacob Pantazis
The Brown and Schisler lab put out a call for rotation students who want a unique co-mentoring opportunity, and Jacob was the first to answer. I had the chance to interview Jacob for his interview into our BBSP program, and it is great to see him in our lab now as a rotation student! He will be working with Selin and the Brown lab on purification and analyses of mutant forms of the enzyme CHIP.
Opening the door for CHIP pharmacology
A new study published from a great collaboration with David Kass, Mark Ranek, and the Hopkins crew is now out at Nature Communications; read and share! Strong work by Becky Sanchez, Cornelia Virus, and Team CHIP.
The Head and the Heart
Great article featuring our ongoing collaboration with the Cohen lab! We are combining forces to biochemically modify the Tau protein, allowing us to understand how Tau functions, both in health and disease, so we can find better ways to treat Alzheimer’s.
Schisler Lab on the cover of JBC
Excited to showcase our latest manuscript that inspired our design of the journal cover. Read the article, co-authored by several undergraduates in our lab!
On The Cover: Functional CHIP is necessary for proper function of the cerebellum. Disease-causing mutations, represented by the space-filled side chains were found in the three functional domains of CHIP: the TPR domain (orange) that binds substrates, the coiled-coil domain (purple and magenta) that mediate the CHIP dimer interaction, and the Ubox (green) that interacts with E2-conjugating enzymes (cyan) through a protein-protein interaction (blue/yellow).